Body 101 · Level Two · Lesson 8 · ages 11 to 12

The Brain and Nervous System In Depth

Our brain weighs about 1.4 kilograms, roughly 2 percent of our body weight, yet it uses about 20 percent of all the energy the body burns. Inside it are about 86 billion neurons, joined by trillions of connection points. This chapter goes deep into how a single neuron sends a signal, which chemicals cross the gap, and what each part of the brain does.

A single neuron on a dark blue background: a round cell body with a purple nucleus, fine branching dendrites, a long axon wrapped in glowing golden myelin segments, and terminals fanning out toward the dendrites of a second neuron at the right edge.
1 · The CellA single neuron

The structure of a neuron

A neuron is shaped like no other cell in the body. It stretches far out so it can send signals over long distances. The longest neuron in us runs from the tip of the toe up to the lower spinal cord, almost a meter long in one single cell. Tap the dots on the picture to see each part.

DendritesAxonAxon terminals
A close-up of a blue axon membrane lined with ion channels; in the middle the channels are open and a burst of golden particles rushes through, while the rest of the membrane stays calm and blue.
2 · ElectricityVoltage and ion channels

A nerve signal is a wave of electricity running along the cell membrane

At rest, the inside of a neuron is about 70 millivolts more negative than the outside. This is called the resting potential. When the cell is stimulated strongly enough, sodium channels open and positively charged sodium rushes in, turning the inside positive. Then potassium channels open to pull the charge back. All of this takes about one thousandth of a second.

+30-70-20Time (milliseconds)
Right now at the resting potential, -70 millivolts

Try it: is it strong enough to fire?

The all-or-none law If the stimulus does not reach threshold, about 15 millivolts above the resting potential, the cell does not fire at all. But once it does reach threshold, it fires at full strength every single time. So the strength of a stimulus is carried by how often it fires not by the size of the signal

The sodium potassium pump keeps pushing the ions back where they started once the signal has passed. That job takes a lot of energy, and it is a big reason why the brain uses one fifth of the body's energy.

A close-up of a synapse: a translucent blue axon terminal on the left holds round vesicles full of golden molecules, releasing them across a narrow gap to cup-shaped receptors on the dendrite surface at the right.
3 · The SynapseNeurotransmitters

At the junction, the signal changes from electrical to chemical

The axon terminal does not really touch the next cell. A very small gap separates them, and that gap is called the synapse. When the electrical signal arrives, tiny sacs release chemicals across the gap to bind to receptors on the next cell. Tap to see what each chemical does.

Medicines and addictive drugs work right hereAlmost every medicine for brain conditions acts at the synapse, for example by raising the amount of a neurotransmitter, keeping it in the gap longer, or blocking its receptor. Many addictive drugs do the same thing, but far more strongly than nature ever does. So the brain adapts, and it keeps needing more and more.
A human brain seen from the left with realistic folds, each region tinted differently: blue frontal lobe, green parietal lobe, orange occipital lobe, red temporal lobe, a purple cerebellum tucked under the back and a yellow brainstem descending from the base.
4 · The MapParts of the brain

Each job lives in a different place in the brain

The brain does not work as one single lump. Each region takes care of a different job, and they stay connected to one another all the time. Tap each lobe of the brain to see what it does.

The body map on the brain The motor strip on the frontal lobe has an area for every part of the body, but the areas are not sized in true proportion. The hands and the mouth take up an enormous amount of space, while the back and the thigh get only a sliver, because we need much finer control of our hands and mouth.
A seated leg with a reflex hammer tapping just below the kneecap; the lower leg kicks forward with slight blur. The leg is translucent, showing muscle and bone, with a glowing golden nerve running from the knee up to the spinal cord and back down to the thigh muscle.
5 · ReflexesA shortcut that skips the brain

Sometimes the spinal cord decides on its own

If your hand touches something hot, you pull it back before you even feel the pain, because the signal runs into the spinal cord and turns straight back out to the muscle without waiting for the brain. Press the button to see the path.

Spinal cordSkin and muscle Sensory fiberMotor fiberTells the brain afterward

Compare the timing

Press to see
50
milliseconds to pull the hand back by reflex
250
milliseconds before you notice the pain

The simplest reflex arc uses only two neurons joined together in the spinal cord, a sensory fiber and a motor fiber. The classic example is tapping the tendon below the knee and watching the leg kick, which doctors use to check whether that stretch of the nerve pathway is working normally.

If this pathway is damaged, the reflex disappears or becomes unusually brisk. So tapping the knee is not a ritual. It really is a test of the body's electrical circuit.

Seven glowing golden glass orbs floating in a row on a dark blue background; the two on the far right are fading and breaking apart into fine sparkles.
6 · MemoryMeasure your own memory

How much can our working memory hold?

Working memory is the brain's temporary holding space, like scratch paper inside your head. Most adults can hold about 7 random digits, plus or minus two. Children aged 11 to 12 usually manage about 6 to 7. Try measuring your own.

Try it: digit span

Ready?

A short string of digits will appear for you to remember, then disappear. Type the whole string back correctly. Each time you get it right, it grows by one more digit.

A trick that psychologists call chunking means that instead of remembering 0 8 1 2 3 4 5 one digit at a time, you remember the chunks 081 2345. The brain can take in far more that way. This is why phone numbers are written in groups.

The hippocampus, the memory factory

New memories are encoded in the hippocampus, which sits deep inside the temporal lobe. Then, while we sleep, those memories are moved out and stored in the cortex. Someone whose hippocampus is damaged on both sides cannot form any new memories at all, even though their old memories are still complete.

Spaced review beats one long cram

Research on learning agrees: several short reviews spread out over time work far better than one long read the night before a test. And testing yourself helps you remember better than just reading it over again. This is why every chapter in this series has a quiz.

Review12 questions

Test yourself

Correct 0 of 12

Fancy a game on this lesson?

Every question from this lesson is in the Body 101 arena. Race the clock, duel someone at home, play as a team, beat the bosses, or practise with no timer at all.